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KMID : 0043319940170060428
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Archives of Pharmacal Research
1994 Volume.17 No. 6 p.428 ~ p.433
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Metabolism and Pharmacokinetics of S-(N,N-Diethyldithiocar-bamoyul)-N-acetyl-L-cysteine in Rats
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Lee Byung-Hoon
Son Yun-Seon
Park Jong-Sei
Ryu Jae-Chun
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Abstract
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The methabolism and phamacokinetics of a mixed disulfide S-(N, N-diethyldithiocarbamoyl)-N-acetyl-L-cysteine (AC-DDTC) were studied in rats. Two metabolites of AC-DDTC following iv and po administration were indentified in plasma and liver by HPLC and GC, namely N, N-diethyldithiocarbamate (DDTC) and the methyl ester of DDTC (Me-DDTC). AC-DDTC was very unstable in vivo and could not be detected neither in plasma nor in urine. Pharmacokinetic parameters of DDTC following intravenous administration of AC-DDTC (20 mg/kg) were calculated. DDTC has a low affinity to rat tissue and the body clearance was . The mean residence time (MRT) was . After oral administration of 20 mg/kg AC-DDTC, maximal plasma concenttion () was and the bioavailability was 7.04%. for DDTC at a dose of 120 mg/kg. AC-DDTC was . ART was .at a dose of 20 mg/kg and at 120 mg/kg.
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KEYWORD
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S-(N, N-diethyldithiocarbamoy)-N-acetyl-L-cysteine, Mixed Disulfide, Disulfiram, Metabolism, pharmacokinetics, High performance Liquid Chromatography, Gas Chromatography
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